PROGRAM STUDI ILMU TEKNOLOGI LABORATORIUM MEDIS (D-3) FAKULTAS ILMU DAN TEKNOLOGI KESEHATAN UNIVERSITAS JENDERAL ACHMAD YANI 2023
VANISA KURNIA, 2350381011
AKTIVITAS FAGOSITOSIS MAKROFAG PADA TIKUS (Rattus norvegicus) MODEL ANEMIA DEFISIENSI ZAT BESI YANG DIBERI SERBUK DAUN BAYAM MERAH (Amaranthus tricolor L)
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ABSTRAK
Anemia defisiensi zat besi dapat menurunkan aktivitas fagositosis makrofag sehingga mengganggu fungsi sistem imun. Serbuk daun bayam merah (Amaranthus tricolor L.) mengandung zat besi dan antioksidan yang berpotensi meningkatkan aktivitas makrofag. Penelitian ini bertujuan menganalisis pengaruh pemberian serbuk daun bayam merah terhadap aktivitas fagositosis makrofag pada tikus (Rattus norvegicus) model anemia defisiensi zat besi. Penelitian menggunakan metode eksperimental in vivo dengan rancangan post-test only control group design. Tikus dibagi menjadi lima kelompok, yaitu normal, anemia, dan tiga kelompok perlakuan dengan dosis 200, 400, dan 600 mg/kgBB. Data dianalisis menggunakan uji One Way ANOVA dan Least Significant Difference (LSD). Hasil menunjukkan adanya perbedaan bermakna antar kelompok (p<0,001). Dosis 600 mg/kgBB memberikan aktivitas fagositosis makrofag tertinggi dan mendekati kelompok normal. Disimpulkan bahwa serbuk daun bayam merah berpengaruh dalam meningkatkan aktivitas fagositosis makrofag pada tikus model anemia defisiensi zat besi.
Kata Kunci:. anemia defisiensi zat besi, fagositosis makrofag, bayam merah Kepustakaan : 35 (2022-2026)

STUDY PROGRAM OF MEDICAL LABORATORY TECHNOLOGY (D-3) FACULTY OF HEALTH SCIENCES AND TECHNOLOGY UNIVERSITY OF JENDERAL ACHMAD YANI 2026
VANISA KURNIA, 2350381011
MACROPHAGE PHAGOCYTOSIS ACTIVITY IN RATS (Rattus norvegicus) IN A MODEL OF IRON DEFICIENCY ANEMIA GIVEN RED AMBER (Amaranthus tricolor L) LEAF POWDER
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ABSTRACT
Iron deficiency anemia can reduce macrophage phagocytic activity, thus disrupting immune system function. Red amaranth leaf powder (Amaranthus tricolor L.) contains iron and antioxidants that have the potential to increase macrophage activity. This study aimed to analyze the effect of administering red amaranth leaf powder on macrophage phagocytic activity in rats (Rattus norvegicus) as a model of iron deficiency anemia. The study used an in vivo experimental method with a post-test only control group design. The rats were divided into five groups: normal, anemic, and three treatment groups with doses of 200, 400, and 600 mg/kgBW. Data were analyzed using One-Way ANOVA and Least Significant Difference (LSD) tests. The results showed a significant difference between the groups (p<0.001). The 600 mg/kgBW dose produced the highest macrophage phagocytic activity, approaching that of the normal group. It was concluded that red amaranth leaf powder is effective in increasing macrophage phagocytic activity in rats as a model of iron deficiency anemia.
Keywords:. iron deficiency anemia, macrophage phagocytosis, red spinach. Literature : 35 (2020-2026)